Small-Molecule Inhibitors of the MDM2-p53 Protein−Protein Interaction Based on an Isoindolinone Scaffold-Reference-Cited by-同舟云学术

Small-Molecule Inhibitors of the MDM2-p53 Protein−Protein Interaction Based on an Isoindolinone Scaffold

Published:2006-09-28 Issue:21 Volume:49 Page:6209-6221
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hardcastle Ian R.¹,Ahmed Shafiq U.¹,Atkins Helen¹,Farnie Gillian¹,Golding Bernard T.¹,Griffin Roger J.¹,Guyenne Sabrina¹,Hutton Claire¹,Källblad Per¹,Kemp Stuart J.¹,Kitching Martin S.¹,Newell David R.¹,Norbedo Stefano¹,Northen Julian S.¹,Reid Rebecca J.¹,Saravanan K.¹,Willems Henriëtte M. G.¹,Lunec John¹

Affiliation:

1. Northern Institute for Cancer Research, School of Natural SciencesChemistry, Bedson Building, University of Newcastle upon Tyne, Newcastle, NE1 7RU, United Kingdom, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, University of Newcastle upon Tyne, Newcastle, NE2 4HH, United Kingdom, and De Novo Pharmaceuticals, Compass House, Vision Park, Histon, Cambridge, CB4 9ZR, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0601194

Reference49 articles.

1. Continents ring the changes

2. Live or let die: the cell's response to p53

3. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

4. Amplification of a gene encoding a p53-associated protein in human sarcomas

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