Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy-Reference-Cited by-同舟云学术

Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy

Published:2013-08-13 Issue:10 Volume:4 Page:948-952
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Alder Catherine M.¹,Ambler Martin¹,Campbell Amanda J.¹,Champigny Aurelie C.¹,Deakin Angela M.¹,Harling John D.¹,Harris Carol A.¹,Longstaff Tim¹,Lynn Sean¹,Maxwell Aoife C.¹,Mooney Chris J.¹,Scullion Callum¹,Singh Onkar M. P.¹,Smith Ian E. D.¹,Somers Donald O.¹,Tame Christopher J.¹,Wayne Gareth¹,Wilson Caroline¹,Woolven James M.¹

Affiliation:

1. Respiratory Therapy Area Unit, GlaxoSmithKline Pharmaceuticals, Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, U.K.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml400206q

Reference22 articles.

1. Regulation of T-cell Responses and Disease by Tec Kinase Itk

2. Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors

3. 5-Aminomethylbenzimidazoles as potent ITK antagonists

4. Discovery and Structure−Activity Relationship of 3-Aminopyrid-2-ones as Potent and Selective Interleukin-2 Inducible T-Cell Kinase (Itk) Inhibitors

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