Structure-Guided Design of A3 Adenosine Receptor-Selective Nucleosides: Combination of 2-Arylethynyl and Bicyclo[3.1.0]hexane Substitutions-Reference-Cited by-同舟云学术

Structure-Guided Design of A3 Adenosine Receptor-Selective Nucleosides: Combination of 2-Arylethynyl and Bicyclo[3.1.0]hexane Substitutions

Published:2012-05-16 Issue:10 Volume:55 Page:4847-4860
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tosh Dilip K.¹,Deflorian Francesca¹,Phan Khai¹,Gao Zhan-Guo¹,Wan Tina C.²,Gizewski Elizabeth²,Auchampach John A.²,Jacobson Kenneth A.¹

Affiliation:

1. Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States

2. Department of Pharmacology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300396n

Reference61 articles.

1. The A3adenosine receptor as multifaceted therapeutic target: pharmacology, medicinal chemistry, and in silico approaches

2. G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactions

3. The Anti-Cancer Effect of A3 Adenosine Receptor Agonists: A Novel, Targeted Therapy

4. Adenosine receptors in colon carcinoma tissues and colon tumoral cell lines: Focus on the A3 adenosine subtype

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