Discovery of a Nanomolar Inhibitor of the Human Murine Double Minute 2 (MDM2)−p53 Interaction through an Integrated, Virtual Database Screening Strategy
Author:
Affiliation:
1. Comprehensive Cancer Center and Departments of Medicinal Chemistry, Internal Medicine, and Pharmacology, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm060023%2B
Reference22 articles.
1. p53, the Cellular Gatekeeper for Growth and Division
2. Surfing the p53 network
3. Live or let die: the cell's response to p53
4. Inhibiting the p53–MDM2 interaction: an important target for cancer therapy
5. p53 Activation by Small Molecules: Application in Oncology
Cited by 122 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. A Green Protocol for One‐Pot Pseudo Five‐Component Synthesis of a New Series of Bis‐Betti Bases Via Mannich‐Type Reaction;ChemistrySelect;2023-01-12
2. Drug Design Methods to Regulate Protein–Protein Interactions;Protein-Protein Interactions;2023
3. Application of In Silico Filtering and Isothermal Titration Calorimetry for the Discovery of Small Molecule Inhibitors of MDM2;Pharmaceuticals;2022-06-16
4. Potential of rescue and reactivation of tumor suppressor p53 for cancer therapy;Biophysical Reviews;2022-01-11
5. Screening of a Focused Ubiquitin-Proteasome Pathway Inhibitor Library Identifies Small Molecules as Novel Modulators of Botulinum Neurotoxin Type A Toxicity;Frontiers in Pharmacology;2021-09-27
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3