Affiliation:
1. Department of Chemistry Payame Noor University (PNU), PO BOX 19395–4697 Tehran Iran
2. Department of Chemistry, Qazvin Branch Islamic Azad University Qazvin Iran
Abstract
AbstractA green multi‐component approach for the synthesis of a new series of bis‐Betti base derivatives via Mannich‐type reaction was developed based on the one‐pot pseudo five‐component reaction of 5,5′‐methylenebis(thiazol‐2‐amine), aromatic aldehydes and 2‐naphthol in the presence of p‐toluenesulfonic acid as organocatalyst under solvent‐free conditions. The attractive features of this method are operational simplicity, metal‐free conditions, environmentally friendly, high atom‐economy, shorter reaction time, broad substrate scope, easy workup procedure, purification of products by nonchromatographic methods and good to high yields.
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1 articles.
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