Use of Small-Molecule Crystal Structures To Address Solubility in a Novel Series of G Protein Coupled Receptor 119 Agonists: Optimization of a Lead and in Vivo Evaluation-Reference-Cited by-同舟云学术

Use of Small-Molecule Crystal Structures To Address Solubility in a Novel Series of G Protein Coupled Receptor 119 Agonists: Optimization of a Lead and in Vivo Evaluation

Published:2012-05-17 Issue:11 Volume:55 Page:5361-5379
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Scott James S.¹,Birch Alan M.¹,Brocklehurst Katy J.¹,Broo Anders²,Brown Hayley S.¹,Butlin Roger J.¹,Clarke David S.¹,Davidsson Öjvind²,Ertan Anne³,Goldberg Kristin¹,Groombridge Sam D.¹,Hudson Julian A.¹,Laber David¹,Leach Andrew G.¹,MacFaul Philip A.¹,McKerrecher Darren¹,Pickup Adrian¹,Schofield Paul¹,Svensson Per H.³,Sörme Pernilla¹,Teague Joanne¹

Affiliation:

1. Cardiovascular & Gastrointestinal Innovative Medicines Unit, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom

2. Cardiovascular & Gastrointestinal Innovative Medicines Unit, AstraZeneca, Pepparedsleden 1, 431 83 Mölndal, Sweden

3. Pharmaceutical Development, AstraZeneca R&D, S-151 85 Södertälje, Sweden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300310c

Reference49 articles.

1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives