Targeting the GPIbα Binding Site of Thrombin To Simultaneously Induce Dual Anticoagulant and Antiplatelet Effects-Reference-Cited by-同舟云学术

Targeting the GPIbα Binding Site of Thrombin To Simultaneously Induce Dual Anticoagulant and Antiplatelet Effects

Published:2014-03-25 Issue:7 Volume:57 Page:3030-3039
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mehta Akul Y.¹,Thakkar Jay N.¹,Mohammed Bassem M.²³,Martin Erika J.²,Brophy Donald F.²,Kishimoto Takao⁴,Desai Umesh R.¹

Affiliation:

1. Department of Medicinal Chemistry and Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia 23219, United States

2. Department of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University, Richmond, Virginia 23298, United States

3. Department of Clinical Pharmacy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt

4. Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Imizu, 939-0398, Japan

Funder

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm4020026

Reference61 articles.

1. Thrombin allostery

2. Ligand Binding Shuttles Thrombin along a Continuum of Zymogen- and Proteinase-like States

3. Thrombin plasticity

4. Allosteric networks in thrombin distinguish procoagulant vs. anticoagulant activities

5. An ensemble view of thrombin allostery

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