Discovery of Novel Agonists and Antagonists of the Free Fatty Acid Receptor 1 (FFAR1) Using Virtual Screening-Reference-Cited by-同舟云学术

Discovery of Novel Agonists and Antagonists of the Free Fatty Acid Receptor 1 (FFAR1) Using Virtual Screening

Published:2008-01-15 Issue:3 Volume:51 Page:625-633
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tikhonova Irina G.¹,Sum Chi Shing¹,Neumann Susanne¹,Engel Stanislav¹,Raaka Bruce M.¹,Costanzi Stefano¹,Gershengorn Marvin C.¹

Affiliation:

1. Laboratory of Biological Modeling, and Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm7012425

Reference25 articles.

1. Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40

2. Fatty acid receptors as new therapeutic targets for diabetes

3. The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse

4. Synthesis and activity of small molecule GPR40 agonists

5. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules

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