Further Studies with the 2-Amino-1,3-thiazol-4(5H)-one Class of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Reducing Pregnane X Receptor Activity and Exploring Activity in a Monkey Pharmacodynamic Model-Reference-Cited by-同舟云学术

Further Studies with the 2-Amino-1,3-thiazol-4(5H)-one Class of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Reducing Pregnane X Receptor Activity and Exploring Activity in a Monkey Pharmacodynamic Model

Published:2008-11-19 Issue:24 Volume:51 Page:7953-7967
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Fotsch Christopher¹,Bartberger Michael D.¹,Bercot Eric A.¹,Chen Michelle¹,Cupples Rod¹,Emery Maury¹,Fretland Jenne¹,Guram Anil¹,Hale Clarence¹,Han Nianhe¹,Hickman Dean¹,Hungate Randall W.¹,Hayashi Michael¹,Komorowski Renee¹,Liu Qingyian¹,Matsumoto Guy¹,St. Jean David J.¹,Ursu Stefania¹,Véniant Murielle¹,Xu Guifen¹,Ye Qiuping¹,Yuan Chester¹,Zhang Jiandong¹,Zhang Xiping¹,Tu Hua¹,Wang Minghan¹

Affiliation:

1. Departments of Chemical Research and Development, Metabolic Disorders, and Pharmacokinetics and Drug Metabolism, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and Amgen Inc., 1120 Veterans Boulevard, South San Francisco, California 94080

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801073z

Reference38 articles.

1. Global Prevalence of Diabetes

2. Inhibition of 11ß-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target

3. 11β-Hydroxysteroid dehydrogenase-1 as a therapeutic target for metabolic diseases

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