1. Department of Biomolecular Medicine, Imperial College London, Division of Surgery, Oncology, Reproductive Biology & Anaesthetics, Faculty of Medicine, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, United Kingdom, Incyte Corporation, Wilmington, Delaware 19880-0400, and Discovery Toxicology, Bristol-Myers Squibb Company, Princeton, New Jersey 08543