Utopia Point Bayesian Optimization Finds Condition-Dependent Selectivity for <i>N</i>-Methyl Pyrazole Condensation-Reference-Cited by-同舟云学术

Utopia Point Bayesian Optimization Finds Condition-Dependent Selectivity for N-Methyl Pyrazole Condensation

Published:2024-05-28 Issue:23 Volume:146 Page:15779-15786
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Dalton Derek M.¹^ORCID,Walroth Richard C.¹,Rouget-Virbel Caroline²,Mack Kyle A.¹^ORCID,Toste F. Dean²^ORCID

Affiliation:

1. Department of Synthetic Molecule Process Chemistry, Genentech, Inc., South San Francisco, California 94080, United States

2. Department of Chemistry, University of California, Berkeley, California 94720, United States

Funder

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.4c01616

Reference39 articles.

1. aFor selected examples of medicinal candidates with N-methyl pyrazoles, see:Zak, M. E.; Rajapaksa, N. S.; Cheng, Y.X.; Grandner, J.; Shore, D. G. M.; Bryan, M. C.Pyrazolopyrimidine Inhibitors of JAK Kinases and Uses Thereof. US 11,453,671 B2, 2022.

2. bZak, M. E.; Rajapaksa, N. S.; Cheng, Y.X.; Grandner, J.; Shore, D. G. M.; Bryan, M. C. Pyrazolopyrimidine Sulfone Inhibitors of JAK Kinases and Uses Thereof. US 20,200,399,275 A1, 2020.

3. Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling

4. dTamura, K.; Yamakawa, T.; Isshiki, S.; Wakiyama, Y.; Ouchi, S.; Matsuhira, T.; Ishida, N.; Tabata, Y. Novel Compound and Pharmacologically Acceptable Salt Thereof. US 201,932,268,6 A1, 2019.

5. eSaito, K.; Nakajima, K.; Taniguchi, T.; Iwamoto, O.; Shibuya, S.; Ogawa, Y.; Aoki, K.; Kurikawa, N.; Tanaka, S.; Ogitani, M.; Kioi, E.; Ito, K.; Nishihama, N.; Mikkaichi, T.; Saitoh, W. Griseofulvin compound. EP 343,810,3 A1, 2019.

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