Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling-Reference-Cited by-同舟云学术

Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling

Published:2019-06 Issue:12 Volume:29 Page:1522-1531
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Zak Mark,Hanan Emily J.,Lupardus Patrick,Brown David G.,Robinson Colin,Siu Michael,Lyssikatos Joseph P.,Romero F. Anthony,Zhao Guiling,Kellar Terry,Mendonca Rohan,Ray Nicholas C.,Goodacre Simon C.,Crackett Peter H.,McLean Neville,Hurley Christopher A.,Yuen Po-wai,Cheng Yun-Xing,Liu Xiongcai,Liimatta Marya,Kohli Pawan Bir,Nonomiya Jim,Salmon Gary,Buckley Gerry,Lloyd Julia,Gibbons Paul,Ghilardi Nico,Kenny Jane R.,Johnson Adam

Funder

Genentech

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference20 articles.

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3. Role of interleukin-13 in asthma;Corren;Curr Allergy Asthma Rep,2013

4. Treatment of atopic dermatitis with tralokinumab, an anti-IL-13 mAb;Wollenberg;J Allergy Clin Immunol,2018

5. Efficacy and safety of lebrikizumab (an anti-IL-13 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical corticosteroids: a randomized, placebo-controlled phase II trial (TREBLE);Simpson;J Am Acad Dermatol,2018

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