Total Synthesis of a PSGL-1 Glycopeptide Analogue for Targeted Inhibition of P-Selectin-Reference-Cited by-同舟云学术

Total Synthesis of a PSGL-1 Glycopeptide Analogue for Targeted Inhibition of P-Selectin

Published:2024-06-12 Issue:25 Volume:146 Page:17414-17427
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Dhakal Bibek¹,Mandhapati Appi¹,Eradi Pradheep¹,Park Simon¹,Fibben Kirby²,Li Kaicheng¹,DeYong Ashley¹,Escopy Samira¹,Karki Geeta¹,Park Diane D.¹,Haller Carolyn A.¹^ORCID,Dai Erbin¹,Sun Lijun¹,Lam Wilbur A.²^ORCID,Chaikof Elliot L.¹³⁴^ORCID

Affiliation:

1. Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, United States

2. Departments of Pediatrics and Biomedical Engineering, Emory University School of Medicine, Atlanta, Georgia 30322, United States

3. Wyss Institute of Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02115, United States

4. Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

National Heart, Lung, and Blood Institute

Harvard Medical School

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.4c05090

Reference77 articles.

1. A Novel Glycosulfopeptide Binds to P-selectin and Inhibits Leukocyte Adhesion to P-selectin

2. Binding of Glycosulfopeptides to P-selectin Requires Stereospecific Contributions of Individual Tyrosine Sulfate and Sugar Residues

3. Noncovalent Association of P-selectin Glycoprotein Ligand-1 and Minimal Determinants for Binding to P-selectin

4. Model Glycosulfopeptides from P-selectin Glycoprotein Ligand-1 Require Tyrosine Sulfation and a Core 2-branched O-Glycan to Bind to L-selectin

5. Cloning of the alpha chain of human platelet glycoprotein Ib: a transmembrane protein with homology to leucine-rich alpha 2-glycoprotein.

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