A Formal Synthesis of (+)-Discodermolide
Author:
Affiliation:
1. Chemical and Analytical Development, Novartis Pharma AG, CH-4002 Basel, Switzerland
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/op049807s
Reference61 articles.
1. Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta
2. Discodermolide, A Cytotoxic Marine Agent That Stabilizes Microtubules More Potently Than Taxol,
3. The best is yet to come
4. The Microtubule-Stabilizing Agent Discodermolide Competitively Inhibits the Binding of Paclitaxel (Taxol) to Tubulin Polymers, Enhances Tubulin Nucleation Reactions More Potently than Paclitaxel, and Inhibits the Growth of Paclitaxel-Resistant Cells
5. The potent microtubule-stabilizing agent (+)-discodermolide induces apoptosis in human breast carcinoma cells???preliminary comparisons to paclitaxel
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