1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1,3-dihydroimidazol-2-one: A Selective High-Affinity Antagonist for the Human Dopamine D4 Receptor with Excellent Selectivity over Ion Channels-Reference-Cited by-同舟云学术

1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1,3-dihydroimidazol-2-one: A Selective High-Affinity Antagonist for the Human Dopamine D4 Receptor with Excellent Selectivity over Ion Channels

Published:1999-06-29 Issue:14 Volume:42 Page:2706-2715
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Carling Robert W.¹,Moore Kevin W.¹,Moyes Christopher R.¹,Jones Elizabeth A.¹,Bonner Katrine¹,Emms Frances¹,Marwood Rosemary¹,Patel Shil¹,Patel Smita¹,Fletcher Alan E.¹,Beer Margaret¹,Sohal Bindi¹,Pike Andrew¹,Leeson Paul D.¹

Affiliation:

1. Departments of Medicinal Chemistry, Biochemistry, and Pharmacology, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm991029k

Reference51 articles.

1. Dopamine receptor pharmacology

2. Molecular cloning and expression of the gene for a human D1 dopamine receptor

3. Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1

4. Cloning of the cDNA and gene for a human D2 dopamine receptor.

5. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

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