Heat Shock Protein 70 Inhibitors. 2. 2,5′-Thiodipyrimidines, 5-(Phenylthio)pyrimidines, 2-(Pyridin-3-ylthio)pyrimidines, and 3-(Phenylthio)pyridines as Reversible Binders to an Allosteric Site on Heat Shock Protein 70-Reference-Cited by-同舟云学术

Heat Shock Protein 70 Inhibitors. 2. 2,5′-Thiodipyrimidines, 5-(Phenylthio)pyrimidines, 2-(Pyridin-3-ylthio)pyrimidines, and 3-(Phenylthio)pyridines as Reversible Binders to an Allosteric Site on Heat Shock Protein 70

Published:2014-02-18 Issue:4 Volume:57 Page:1208-1224
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Taldone Tony¹,Kang Yanlong¹,Patel Hardik J.¹,Patel Maulik R.¹,Patel Pallav D.¹,Rodina Anna¹,Patel Yogita²,Gozman Alexander¹,Maharaj Ronnie¹,Clement Cristina C.¹,Lu Alvin¹,Young Jason C.²,Chiosis Gabriela¹

Affiliation:

1. Program in Molecular Pharmacology and Chemistry and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, United States

2. Groupe de Recherche Axé sur la Structure des Protéines, Department of Biochemistry, McGill University, Montreal, Quebec, Canada H3G 0B1

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401552y

Reference37 articles.

1. Hsp70 chaperones: Cellular functions and molecular mechanism

2. Molecular Chaperones and Protein Quality Control

3. Targeting HSP70: The second potentially druggable heat shock protein and molecular chaperone?

4. Hsp70: Anti-apoptotic and Tumorigenic Protein

5. Hsp70 Molecular Chaperones: Emerging Roles in Human Disease and Identification of Small Molecule Modulators

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