Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3′-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides-Reference-Cited by-同舟云学术

Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3′-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides

Published:2011-09-22 Issue:41 Volume:133 Page:16642-16649
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Egli Martin¹,Pallan Pradeep S.¹,Allerson Charles R.²,Prakash Thazha P.²,Berdeja Andres²,Yu Jinghua²,Lee Sam²,Watt Andrew²,Gaus Hans²,Bhat Balkrishen²,Swayze Eric E.²,Seth Punit P.²

Affiliation:

1. Department of Biochemistry, School of Medicine, Vanderbilt University, 607 Light Hall, Nashville, Tennessee 37232, United States

2. Isis Pharmaceuticals Inc., 1891 Rutherford Road, Carlsbad, California 92008, United States

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja207086x

Reference32 articles.

1. RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

2. Control of translation and mRNA degradation by miRNAs and siRNAs: Table 1.