A Substrate Selectivity and Inhibitor Design Lesson from the PDE10−cAMP Crystal Structure: A Computational Study
Author:
Affiliation:
1. Department of Chemistry, The Hong Kong Baptist University, Waterloo Road, Kowloon Tong, Kowloon, Hong Kong, China
Publisher
American Chemical Society (ACS)
Subject
Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/jp911156g
Reference55 articles.
1. Studies on the Mechanism of Hormone Action
2. Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide Signaling
3. Overview of PDEs and Their Regulation
4. Cyclic nucleotide phosphodiesterases and their role in endocrine cell signaling
5. Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions
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3. An update view on the substrate recognition mechanism of phosphodiesterases: A computational study of PDE10 and PDE4 bound with cyclic nucleotides;Biopolymers;2012-08-13
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