Catalytic Mechanism of Class A β-Lactamase: Role of Lysine 73 and C3-Carboxyl Group of the Substrate Pen G in the Deacylation Step
Author:
Affiliation:
1. Laboratory of Physical Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan
Publisher
American Chemical Society (ACS)
Subject
Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/jp021414c
Reference72 articles.
1. Contribution of mutant analysis to the understanding of enzyme catalysis: The case of class A β-lactamases
2. Site-directed mutagenesis of β-lactamase I. Single and double mutants of Glu-166 and Lys-73
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