Penicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition-Reference-Cited by-同舟云学术

Penicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition

Published:2022-06-28 Issue:3 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Hinchliffe Philip¹^ORCID,Tooke Catherine L.¹^ORCID,Bethel Christopher R.²,Wang Benlian³,Arthur Christopher⁴,Heesom Kate J.⁵,Shapiro Stuart⁶,Schlatzer Daniela M.³,Papp-Wallace Krisztina M.²⁷⁸^ORCID,Bonomo Robert A.²⁷⁸⁹¹⁰^ORCID,Spencer James¹

Affiliation:

1. School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom

2. Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA

3. Department of Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

4. School of Chemistry, University of Bristol, Bristol, United Kingdom

5. Proteomics Facility, Faculty of Life Sciences, University of Bristol, Bristol, United Kingdom

6. Allecra Therapeutics SAS, Saint-Louis, France

7. Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

8. Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

9. Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

10. Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

Abstract

β-Lactams are the most prescribed antibiotic class for treating bacterial diseases, but their continued efficacy is threatened by bacterial strains producing β-lactamase enzymes that catalyze their inactivation. The CTX-M family of ESBLs are major contributors to β-lactam resistance in Enterobacterales , preventing effective treatment with most penicillins and cephalosporins.

Funder

UKRI | Biotechnology and Biological Sciences Research Council

Allecra Therapeutics

Cleveland Department of Veterans Affairs, the Veteran Affairs Merit Review Program

Cleveland Department of Veterans Affairs, the Biomedical Laboratory Research & Development Service of the VA Office of Research and Development

VA | Geriatric Research Education and Clinical Center

HHS | NIH | National Institute of Allergy and Infectious Diseases

UKRI | Medical Research Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology