Analysis of Kinase Inhibitor Selectivity using a Thermodynamics-Based Partition Index-Reference-Cited by-同舟云学术

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Analysis of Kinase Inhibitor Selectivity using a Thermodynamics-Based Partition Index

Published:2010-05-11 Issue:11 Volume:53 Page:4502-4510
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cheng Alan C.¹,Eksterowicz John²,Geuns-Meyer Stephanie³,Sun Yaxiong⁴

Affiliation:

1. Molecular Structure Department

2. Molecular Structure Department, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, California 94080

3. Medicinal Chemistry Department

4. Molecular Structure Department, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm100301x

Reference22 articles.

1. The Protein Kinase Complement of the Human Genome

2. Protein Kinase Inhibitors: Insights into Drug Design from Structure

3. A small molecule–kinase interaction map for clinical kinase inhibitors

4. Signal Transduction Therapy with Rationally Designed Kinase Inhibitors

5. Measuring and interpreting the selectivity of protein kinase inhibitors

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1. Discovery and Optimization of N-Heteroaryl Indazole LRRK2 Inhibitors;Journal of Medicinal Chemistry;2024-09-04

2. KinomeMETA: a web platform for kinome-wide polypharmacology profiling with meta-learning;Nucleic Acids Research;2024-05-16

3. Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting;eLife;2023-12-04

4. Death by a Thousand Cuts – Combining Kinase Inhibitors for Selective Target Inhibition and Rational Polypharmacology;2023-01-16

5. Synthesis of Palladium‐Catalysed C−C Bond Forming 5‐Chloro Quinolines via Suzuki‐Miyaura Coupling; Anti‐Pancreatic Cancer Screening on PANC‐1 Cell Lines;Chemistry & Biodiversity;2022-12-13

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