Oridonin Ring A-Based Diverse Constructions of Enone Functionality: Identification of Novel Dienone Analogues Effective for Highly Aggressive Breast Cancer by Inducing Apoptosis

Author:

Ding Chunyong1,Zhang Yusong23,Chen Haijun1,Yang Zhengduo3,Wild Christopher1,Ye Na1,Ester Corbin D.3,Xiong Ailian3,White Mark A.4,Shen Qiang3,Zhou Jia1

Affiliation:

1. Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States

2. Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215004, China

3. Department of Clinical Cancer Prevention, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States

4. Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, Texas 77555, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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