Discovery of Pteridin-7(8H)-one-Based Irreversible Inhibitors Targeting the Epidermal Growth Factor Receptor (EGFR) Kinase T790M/L858R Mutant-Reference-Cited by-同舟云学术

Discovery of Pteridin-7(8H)-one-Based Irreversible Inhibitors Targeting the Epidermal Growth Factor Receptor (EGFR) Kinase T790M/L858R Mutant

Published:2013-10-09 Issue:20 Volume:56 Page:7821-7837
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhou Wei¹,Liu Xiaofeng¹,Tu Zhengchao²,Zhang Lianwen²,Ku Xin³,Bai Fang,Zhao Zhenjiang¹,Xu Yufang¹,Ding Ke²,Li Honglin¹

Affiliation:

1. Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, China

2. Key Laboratory of Regenerative Biology and Institute of Chemical Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China

3. Lehrstuhl für Proteomik und Bioanalytik, Technische Universität München, Freising 85354, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401045n

Reference52 articles.

1. EGFR Antagonists in Cancer Treatment

2. NEW EMBO MEMBERS' REVIEW: The ErbB signaling network: receptor heterodimerization in development and cancer

3. Epidermal growth factor receptor mutations in lung cancer

4. Design and Synthesis of Tetrahydropyridothieno[2,3-d]pyrimidine Scaffold Based Epidermal Growth Factor Receptor (EGFR) Kinase Inhibitors: The Role of Side Chain Chirality and Michael Acceptor Group for Maximal Potency

5. Correction: Targeted therapy in non-small-cell lung cancer—is it becoming a reality?

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