Covalent Allosteric Inhibitors of Akt Generated Using a Click Fragment Approach-Reference-Cited by-同舟云学术

Covalent Allosteric Inhibitors of Akt Generated Using a Click Fragment Approach

Published:2022-03-09 Issue:10 Volume:17 Page:
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Westhuizen Leandi¹,Weisner Jörn²³,Taher Abu¹,Landel Ina²³,Quambusch Lena²³,Lindemann Marius²³,Uhlenbrock Niklas²³,Müller Matthias P.²³,Green Ivan R.¹,Pelly Stephen C.¹⁴,Rauh Daniel²³,Otterlo Willem A. L.¹

Affiliation:

1. Department of Chemistry and Polymer Science Stellenbosch University Matieland 7602 South Africa

2. Faculty of Chemistry and Chemical Biology TU Dortmund University Otto-Hahn-Strasse 4a 44227 Dortmund Germany

3. Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW) 44227 Dortmund Germany

4. Department of Chemistry Emory University 1515 Dickey Drive Atlanta GA 30322 USA

Funder

South African Medical Research Council

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202100776

Reference54 articles.

2. PI3K and cancer: lessons, challenges and opportunities

3. AKT/PKB Signaling: Navigating Downstream

4. Protein kinase B/Akt at a glance

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