Protein kinase B/Akt at a glance
Author:
Affiliation:
1. Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
Publisher
The Company of Biologists
Subject
Cell Biology
Link
http://journals.biologists.com/jcs/article-pdf/118/24/5675/1522931/5675.pdf
Reference48 articles.
1. Alessi, D. R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P. and Hemmings, B. A. (1996). Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J.15, 6541-6551.
2. Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B. and Cohen, P. (1997). Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr. Biol.7, 261-269.
3. Andjelkovic, M., Jakubowicz, T., Cron, P., Ming, X. F., Han, J. W. and Hemmings, B. A. (1996). Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. Proc. Natl. Acad. Sci. USA93, 5699-5704.
4. Andjelkovic, M., Maira, S. M., Cron, P., Parker, P. J. and Hemmings, B. A. (1999). Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase. Mol. Cell. Biol.19, 5061-5072.
5. Arboleda, M. J., Lyons, J. F., Kabbinavar, F. F., Bray, M. R., Snow, B. E., Ayala, R., Danino, M., Karlan, B. Y. and Slamon, D. J. (2003). Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells. Cancer Res.63, 196-206.
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