Nerve Growth Factor-Preconditioned Mesenchymal Stem Cell-Derived Exosome-Functionalized 3D-Printed Hierarchical Porous Scaffolds with Neuro-Promotive Properties for Enhancing Innervated Bone Regeneration

Author:

Lian Meifei12,Qiao Zhiguang23,Qiao Shichong1,Zhang Xing4,Lin Jieming3,Xu Ruida3,Zhu Naifeng3,Tang Tianhong5,Huang Zhuoli1,Jiang Wenbo2,Shi Junyu1,Hao Yongqiang26ORCID,Lai Hongchang1,Dai Kerong26ORCID

Affiliation:

1. Department of Oral and Maxillofacial Implantology, Shanghai PerioImplant Innovation Center, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai 200011, China

2. Clinical and Translational Research Center for 3D Printing Technology, Medical 3D Printing Innovation Research Center, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200125, China

3. Department of Bone and Joint Surgery, Department of Orthopedics, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China

4. State Key Laboratory of Mechanical Systems and Vibration, Shanghai Jiao Tong University, Shanghai 200240, China

5. Department of Prosthodontics, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

6. Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

Funder

Shanghai Jiao Tong University

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Biomaterials and Regenerative Medicine Institute Cooperative Research Project by Shanghai JiaoTong University School of Medicine

Publisher

American Chemical Society (ACS)

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