Selection of Fluorescent, Bioluminescent, and Radioactive Tracers to Accurately Reflect Extracellular Vesicle Biodistribution in Vivo-Reference-Cited by-同舟云学术

Selection of Fluorescent, Bioluminescent, and Radioactive Tracers to Accurately Reflect Extracellular Vesicle Biodistribution in Vivo

Published:2021-01-20 Issue:2 Volume:15 Page:3212-3227
ISSN:1936-0851
Container-title:ACS Nano
language:en
Short-container-title:ACS Nano

Author:

Lázaro-Ibáñez Elisa¹²^ORCID,Faruqu Farid N.³,Saleh Amer F.⁴,Silva Andreia M.¹,Tzu-Wen Wang Julie³,Rak Janusz⁵^ORCID,Al-Jamal Khuloud T.³^ORCID,Dekker Niek¹^ORCID

Affiliation:

1. Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg 43150, Sweden

2. Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceutical R&D, AstraZeneca, Gothenburg 43150, Sweden

3. Institute of Pharmaceutical Science, School of Cancer & Pharmaceutical Sciences, King’s College London, London SE1 9NH, United Kingdom

4. Functional and Mechanistic Safety, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 0AA, United Kingdom

5. Research Institute of the McGill University Health Centre, Glen Site, McGill University, Montreal, Quebec H4A 3J,1 Canada

Funder

Brain Tumour Charity

Majlis Amanah Rakyat

British Council

Wellcome Trust

Publisher

American Chemical Society (ACS)

Subject

General Physics and Astronomy,General Engineering,General Materials Science

Link

http://pubs.acs.org/doi/pdf/10.1021/acsnano.0c09873

Reference60 articles.

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4. Extracellular vesicles induce minimal hepatotoxicity and immunogenicity

5. Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells

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