Design of SARS-CoV-2 hFc-Conjugated Receptor-Binding Domain mRNA Vaccine Delivered via Lipid Nanoparticles

Author:

Elia Uri12345,Ramishetti Srinivas1234,Rosenfeld Ronit5,Dammes Niels1234,Bar-Haim Erez5,Naidu Gonna Somu1234,Makdasi Efi6,Yahalom-Ronen Yfat6,Tamir Hadas6,Paran Nir6,Cohen Ofer5,Peer Dan1234ORCID

Affiliation:

1. Laboratory of Precision NanoMedicine, Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel

2. Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv 69978, Israel

3. Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel

4. Cancer Biology Research Center, Tel Aviv University, Tel Aviv 69978, Israel

5. Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona 76100, Israel

6. Department of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona 76100, Israel

Funder

Lewis Trust

Publisher

American Chemical Society (ACS)

Subject

General Physics and Astronomy,General Engineering,General Materials Science

Reference39 articles.

1. Coronavirus Disease (COVID-19), World Health Organization, Oct. 11, 2020; https://www.who.int/docs/default-source/coronaviruse/situation-reports/20201012-weekly-epi-update-9.pdf (accessed 2020-10-12).

2. Draft Landscape of COVID-19 Candidate Vaccines, World Health Organization; https://www.who.int/publications/m/item/draft-landscape-of-covid-19-candidate-vaccines (accessed 2020-10-02).

3. An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

4. Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

5. Advances in RNAi therapeutic delivery to leukocytes using lipid nanoparticles

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