Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe In Situ Gene Editing in Human Skin

Author:

Bolsoni Juliana1,Liu Danny1,Mohabatpour Fatemeh1,Ebner Ronja1,Sadhnani Gaurav2,Tafech Belal1,Leung Jerry3,Shanta Selina1,An Kevin4,Morin Tessa1,Chen Yihang3,Arguello Alfonso5,Choate Keith6,Jan Eric3,Ross Colin J.D.1,Brambilla Davide5ORCID,Witzigmann Dominik4,Kulkarni Jayesh4,Cullis Pieter R.3ORCID,Hedtrich Sarah1278ORCID

Affiliation:

1. Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver V6T 1Z3, BC, Canada

2. Berlin Institute of Health @ Charité Universitätsmedizin, Berlin 10117, Germany

3. Department of Biochemistry and Molecular Biology, University of British Columbia, 2350 Health Sciences Mall, Vancouver V6T 1Z3, BC, Canada

4. NanoVation Therapeutics, 2405 Wesbrook Mall, Vancouver V6T 1Z3, BC, Canada

5. University of Montréal, Faculty of Pharmacy, Montréal H3T 1J4, Quebec, Canada

6. Departments of Dermatology, Genetics, and Pathology, Yale University School of Medicine, New Haven 06510, Connecticut, United States

7. Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität, Berlin 10117, Germany

8. Max-Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin 13125, Germany

Funder

Canadian Institutes of Health Research

LEO Fondet

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Faculty of Pharmaceutical Sciences, University of British Columbia

NanoMedicines Innovation Network

Stiftung Charité

Publisher

American Chemical Society (ACS)

Subject

General Physics and Astronomy,General Engineering,General Materials Science

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