Cationic Amphiphilic Drugs Boost the Lysosomal Escape of Small Nucleic Acid Therapeutics in a Nanocarrier-Dependent Manner

Author:

Van de Vyver Thijs1ORCID,Bogaert Bram1,De Backer Lynn1,Joris Freya1,Guagliardo Roberta1,Van Hoeck Jelter1,Merckx Pieterjan1ORCID,Van Calenbergh Serge2ORCID,Ramishetti Srinivas,Peer DanORCID,Remaut Katrien1,De Smedt Stefaan C.1ORCID,Raemdonck Koen1

Affiliation:

1. Ghent Research Group on Nanomedicines, Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium

2. Laboratory for Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium

Funder

H2020 Marie Sklodowska-Curie Actions

Fonds Wetenschappelijk Onderzoek

Agentschap voor Innovatie door Wetenschap en Technologie

Bijzonder Onderzoeksfonds

Publisher

American Chemical Society (ACS)

Subject

General Physics and Astronomy,General Engineering,General Materials Science

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