Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MS-Reference-Cited by-同舟云学术

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Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MS

Published:2010-11-09 Issue:2 Volume:2 Page:97-101
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Saha Ashis K.¹,Yu Xiang¹,Lin Jian¹,Lobera Mercedes¹,Sharadendu Anurag¹,Chereku Srinivas¹,Schutz Nili¹,Segal Dalia¹,Marantz Yael¹,McCauley Dilara¹,Middleton Scot²,Siu Jerry²,Bürli Roland W.³,Buys Janet⁴,Horner Michelle⁴,Salyers Kevin⁵,Schrag Michael⁵,Vargas Hugo M.⁴,Xu Yang⁵,McElvain Michele⁶,Xu Han⁶

Affiliation:

1. EPIX Pharmaceuticals Inc., 167 Worcester Street, Suite 201, Wellesley Hills, Massachusetts 02481, United States

2. Inflammation Research

3. Departments of Medicinal Chemistry

4. Comparative Biology and Safety Sciences

5. Pharmacokinetics and Drug Metabolism

6. Molecular Pharmacology

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml100227q

Reference19 articles.

1. Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis

2. A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

3. Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

4. FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system

5. Brain Penetration of the Oral Immunomodulatory Drug FTY720 and Its Phosphorylation in the Central Nervous System during Experimental Autoimmune Encephalomyelitis: Consequences for Mode of Action in Multiple Sclerosis

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