IgG3 Is the Dominant Subtype of Anti-isoniazid Antibodies in Patients with Isoniazid-Induced Liver Failure

Author:

Metushi Imir G.1,Lee William M.2,Uetrecht Jack1

Affiliation:

1. Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada

2. Division of Digestive and Liver Disease, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas 75390, United States

Funder

Canadian Institutes of Health Research

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Reference22 articles.

1. Centers for Disease Control and Prevention (2010) Severe Isoniazid-Associated Liver Injuries among Persons Being Treated for Latent Tuberculosis Infection - United States, 2004–2008,Morbidity and Mortality Weekly Report, Vol.59, pp224–229,Centers for Disease Control and Prevention,Atlanta, GA.

2. Isoniazid Liver Injury: Clinical Spectrum, Pathology, and Probable Pathogenesis

3. Isoniazid Hepatitis

4. Isoniazid-Associated Hepatitis in 114 Patients

5. Direct Oxidation and Covalent Binding of Isoniazid to Rodent Liver and Human Hepatic Microsomes: Humans Are More Like Mice than Rats

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