Direct Oxidation and Covalent Binding of Isoniazid to Rodent Liver and Human Hepatic Microsomes: Humans Are More Like Mice than Rats
Author:
Affiliation:
1. Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
2. Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
Publisher
American Chemical Society (ACS)
Subject
Toxicology,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/tx300341r
Reference26 articles.
1. Isoniazid Liver Injury: Clinical Spectrum, Pathology, and Probable Pathogenesis
2. Isoniazid and Iproniazid: Activation of Metabolites to Toxic Intermediates in Man and Rat
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