New Proline Mimetics: Synthesis of Thrombin Inhibitors Incorporating Cyclopentane- and Cyclopentenedicarboxylic Acid Templates in the P2 Position. Binding Conformation Investigated by X-ray Crystallography-Reference-Cited by-同舟云学术

New Proline Mimetics: Synthesis of Thrombin Inhibitors Incorporating Cyclopentane- and Cyclopentenedicarboxylic Acid Templates in the P2 Position. Binding Conformation Investigated by X-ray Crystallography

Published:2000-04-14 Issue:9 Volume:43 Page:1705-1713
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Nöteberg Daniel¹,Brånalt Jonas¹,Kvarnström Ingemar¹,Linschoten Marcel¹,Musil Djordje¹,Nyström Jan-Erik¹,Zuccarello Guido¹,Samuelsson Bertil¹

Affiliation:

1. Department of Chemistry, Linköping University, S-581 83 Linköping, Sweden, Department of Medicinal Chemistry, AstraZeneca, S-431 83 Mölndal, Sweden, and Department of Organic Chemistry, Stockholm University, S-106 91 Stockholm, Sweden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm990557t

Reference40 articles.

1. Design principles for orally bioavailable drugs

2. Progress in the discovery of orally bioavailable inhibitors of HIV protease

3. Case histories of peptidomimetics: Progression from peptides to drugs

4. Antithrombotic agents

5. The coagulation cascade: initiation, maintenance, and regulation

Cited by 34 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Catalytic Reduction of Aromatic Nitro Compounds to Phenylhydroxylamine and Its Derivatives;Molecules;2024-09-13

2. An Overview of Thrombin Inhibitors in the Perspective of Structureactivity Relationships;Current Medicinal Chemistry;2023-08

3. Design of Pseudodiproline Dimers as Mimetics of Pro-Pro Units: Stereocontrolled Synthesis, Configurational Relevance, and Structural Properties;The Journal of Organic Chemistry;2021-11-09

4. Mimicking a proline tripeptide with pyrazolidines and a cyclopentane linker;Tetrahedron Letters;2015-12

5. Acid-induced atypical spontaneous conversion of 5-amino-2,6-dioxooctahydro-1H-pyrrolo[2,1-d][1,5]oxazocine into 4-(hydroxymethyl)-2,5-dioxooctahydro-1H-pyrrolo[1,2-d][1,4]diazepine;Research on Chemical Intermediates;2014-09-18