Molecular Basis for Inhibition of GH84 Glycoside Hydrolases by Substituted Azepanes: Conformational Flexibility Enables Probing of Substrate Distortion-Reference-Cited by-同舟云学术

Molecular Basis for Inhibition of GH84 Glycoside Hydrolases by Substituted Azepanes: Conformational Flexibility Enables Probing of Substrate Distortion

Published:2009-03-30 Issue:15 Volume:131 Page:5390-5392
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Marcelo Filipa¹,He Yuan¹,Yuzwa Scott A.¹,Nieto Lidia¹,Jiménez-Barbero Jesús¹,Sollogoub Matthieu¹,Vocadlo David J.¹,Davies Gideon D.¹,Blériot Yves¹

Affiliation:

1. UPMC Univ Paris 06, Institut Parisien de Chimie Moléculaire, UMR CNRS 7201, Equipe glycochimie, C181, 4 place Jussieu, 75005 Paris, France, Department of Chemistry, The University of York, Heslington, York, U.K., Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, Canada, and Centro de Investigaciones Biológicas, CSIC, Madrid, Spain

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja809776r

Reference40 articles.

1. Glycan Antagonists and Inhibitors: A Fount for Drug Discovery

2. Recent Developments of Transition-State Analogue Glycosidase Inhibitors of Non-Natural Product Origin

3. Structure and synthesis of nojirimycin

4. Noeuromycin,1 A Glycosyl Cation Mimic that Strongly Inhibits Glycosidases

Cited by 66 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The emerging polyhydroxyazepane-based C-glycosides for glycosidase inhibition;Synthetic Strategies in Carbohydrate Chemistry;2024

2. Evaluation of nonnatural L-iminosugar C,C-glycosides, a new class of C-branched iminosugars, as glycosidase inhibitors;Carbohydrate Research;2023-10

3. Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitors;Organic & Biomolecular Chemistry;2022

4. Sugar-Derived Amidines and Congeners: Structures, Glycosidase Inhibition and Applications;Current Medicinal Chemistry;2021-12-22

5. Discovery of a Novel and Brain-Penetrant O-GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization;Journal of Medicinal Chemistry;2021-01-06