Planarity and Constraint of the Carbonyl Groups in 1,2-Diones Are Determinants for Selective Inhibition of Human Carboxylesterase 1-Reference-Cited by-同舟云学术

Planarity and Constraint of the Carbonyl Groups in 1,2-Diones Are Determinants for Selective Inhibition of Human Carboxylesterase 1

Published:2007-10-17 Issue:23 Volume:50 Page:5727-5734
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hyatt Janice L.¹,Wadkins Randy M.¹,Tsurkan Lyudmila¹,Hicks Latorya D.¹,Hatfield M. Jason¹,Edwards Carol C.¹,Ross Charles R.¹,Cantalupo Stephanie A.¹,Crundwell Guy¹,Danks Mary K.¹,Guy R. Kip¹,Potter Philip M.¹

Affiliation:

1. Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, Department of Chemistry and Biochemistry, University of Mississippi, University, Mississippi 38677, Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, Department of Chemistry and Biochemistry, Central Connecticut State University, New Britain, Connecticut 06050, and Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital,...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0706867

Reference45 articles.

1. Anomalous nonidentity between Salmonella genotoxicants and rodent carcinogens: nongenotoxic carcinogens and genotoxic noncarcinogens.

2. Purification and Cloning of a Broad Substrate Specificity Human Liver Carboxylesterase That Catalyzes the Hydrolysis of Cocaine and Heroin

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