The Crystal Structure of a Complex of Acetylcholinesterase with a Bis-(−)-nor-meptazinol Derivative Reveals Disruption of the Catalytic Triad-Reference-Cited by-同舟云学术

The Crystal Structure of a Complex of Acetylcholinesterase with a Bis-(−)-nor-meptazinol Derivative Reveals Disruption of the Catalytic Triad

Published:2009-03-27 Issue:8 Volume:52 Page:2543-2549
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Paz Aviv¹,Xie Qiong¹,Greenblatt Harry M.¹,Fu Wei¹,Tang Yun¹,Silman Israel¹,Qiu Zhuibai¹,Sussman Joel L.¹

Affiliation:

1. Departments of Structural Biology and Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel, Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 200032, P.R. China, School of Pharmacy, East China University of Science and Technology, Shanghai 200237 P.R. China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801657v

Reference38 articles.

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4. The rationale for E2020 as a potent acetylcholinesterase inhibitor

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