Enantioselective synthesis of novel pyrano[3,2-c]chromene derivatives as AChE inhibitors via an organocatalytic domino reaction-Reference-Cited by-同舟云学术

Enantioselective synthesis of novel pyrano[3,2-c]chromene derivatives as AChE inhibitors via an organocatalytic domino reaction

Published:2018 Issue:3 Volume:16 Page:472-479
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zheng Jie¹²³⁴⁵,He Ming¹²³⁴⁵,Xie Baohua¹²³⁴⁵,Yang Lu¹²³⁴⁵,Hu Zhiye¹²³⁴⁵,Zhou Hai-Bing¹²³⁴⁵^ORCID,Dong Chune¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Virology

2. Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals

3. Wuhan University School of Pharmaceutical Sciences

4. Wuhan 430071

5. China

Abstract

Novel optically active pyrano[3,2-c]chromenes have been synthesized (up to 94% yield, 99% ee) through an asymmetric catalytic domino reaction and identified as potent acetylcholinesterase inhibitors. In most cases, the S-enantiomers were superior to R-enantiomers.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C7OB02794J

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