Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 2. Leveraging Structure-Based Drug Design to Identify Analogues with Improved Pharmacokinetic Profiles-Reference-Cited by-同舟云学术

Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 2. Leveraging Structure-Based Drug Design to Identify Analogues with Improved Pharmacokinetic Profiles

Published:2014-01-09 Issue:2 Volume:57 Page:325-338
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

St. Jean David J.¹,Ashton Kate S.¹,Bartberger Michael D.¹,Chen Jie¹,Chmait Samer¹,Cupples Rod¹,Galbreath Elizabeth¹,Helmering Joan¹,Hong Fang-Tsao¹,Jordan Steven R.¹,Liu Longbin¹,Kunz Roxanne K.¹,Michelsen Klaus¹,Nishimura Nobuko¹,Pennington Lewis D.¹,Poon Steve F.¹,Reid Darren¹,Sivits Glenn¹,Stec Markian M.¹,Tadesse Seifu¹,Tamayo Nuria¹,Van Gwyneth¹,Yang Kevin C.¹,Zhang Jiandong¹,Norman Mark H.¹,Fotsch Christopher¹,Lloyd David J.¹,Hale Clarence¹

Affiliation:

1. Department of Therapeutic Discovery—Medicinal Chemistry, ‡Department of Therapeutic Discovery—Molecular Structure and Characterization, §Department of Metabolic Disorders, ∥Department of Pharmacokinetics and Drug Metabolism, ⊥Department of Pathology, #Department of Pharmaceutics Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California, 91320 and 360 Binney Street, Cambridge, Massachusetts, 02142, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm4016747

Reference22 articles.

1. GKAs for diabetes therapy: why no clinically useful drug after two decades of trying?

2. Glucokinase Regulatory Network in Pancreatic β-Cells and Liver

3. Glucokinase activators in diabetes management

4. Small molecular glucokinase activators: has another new anti-diabetic therapeutic lost favour?

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