Small molecular glucokinase activators: has another new anti-diabetic therapeutic lost favour?
Author:
Affiliation:
1. Oxford Centre for Diabetes Endocrinology & Metabolism; University of Oxford; Oxford; UK
Publisher
Wiley
Subject
Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1476-5381.2012.02201.x/fullpdf
Reference16 articles.
1. The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver;Beer;Hum Mol Genet,2009
2. Piragliatin (RO4389620), a novel glucokinase activator, lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus: a mechanistic study;Bonadonna;J Clin Endocrinol Metab,2010
3. Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humans;De Ceuninck;Brit J Pharmacol,2012
4. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk;Dupuis;Nat Genet,2010
5. Long-term overexpression of glucokinase in the liver of transgenic mice leads to insulin resistance;Ferre;Diabetologia,2003
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