Small-Molecule Inhibitors of Cytokine-Mediated STAT1 Signal Transduction in β-Cells with Improved Aqueous Solubility-Reference-Cited by-同舟云学术

Small-Molecule Inhibitors of Cytokine-Mediated STAT1 Signal Transduction in β-Cells with Improved Aqueous Solubility

Published:2013-05-13 Issue:10 Volume:56 Page:4125-4129
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Scully Stephen S.¹,Tang Alicia J.¹,Lundh Morten¹²,Mosher Carrie M.¹,Perkins Kedar M.¹,Wagner Bridget K.¹

Affiliation:

1. Chemical Biology Program and Chemical Biology Platform, The Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, United States

2. Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm400397x

Reference24 articles.

1. Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in β-Cells

2. Silymarin Protects Pancreatic β-Cells against Cytokine-Mediated Toxicity: Implication of c-Jun NH2-Terminal Kinase and Janus Kinase/Signal Transducer and Activator of Transcription Pathways

3. Flavonoids Protect Against Cytokine-Induced Pancreatic β-Cell Damage Through Suppression of Nuclear Factor κB Activation

4. Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells

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