Practical Formal Total Syntheses of the Homocamptothecin Derivative and Anticancer Agent Diflomotecan via Asymmetric Acetate Aldol Additions to Pyridine Ketone Substrates-Reference-Cited by-同舟云学术

Practical Formal Total Syntheses of the Homocamptothecin Derivative and Anticancer Agent Diflomotecan via Asymmetric Acetate Aldol Additions to Pyridine Ketone Substrates

Published:2006-09-01 Issue:20 Volume:71 Page:7583-7595
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Peters René¹,Althaus Martin¹,Diolez Christian¹,Rolland Alain¹,Manginot Eric¹,Veyrat Marc¹

Affiliation:

1. F. Hoffmann-La Roche Ltd., Pharmaceuticals Division, Safety & Technical Sciences, Synthesis and Process Research, Grenzacherstr. 124, CH-4070 Basel, Switzerland, Ipsen, avenue du Canada, F-91966 Les Ulis, France, and Expansia, route d'Avignon, F-30390 Aramon, France

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo060928v

Reference25 articles.

1. Camptothecin: current perspectives

2. Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2

3. Alkyl Esters of Camptothecin and 9-Nitrocamptothecin: Synthesis, in Vitro Pharmacokinetics, Toxicity, and Antitumor Activity

4. Topoisomerase I-Mediated Antiproliferative Activity of Enantiomerically Pure Fluorinated Homocamptothecins

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