Affiliation:
1. Department of Medicinal Chemistry and Biology, International Humanitarian University, 25A, Fontanskaya Road, Odessa, 65009,
Ukraine
Abstract
Abstract:
Over the past 55 years of research, various experimental methods have been developed for the total synthesis
of the anticancer camptothecin, a potent antitumor antibiotic, and its numerous active derivatives. The discoveries
made in synthetic pathways of the camptothecin heterocyclic core have contributed significantly to the theory and
strategy of directed organic synthesis aimed at finding effective anticancer drugs. The synthetic, medicinal chemistry
of camptothecin, the development of structures of anticancer camptothecin analogues, and the mechanism of their
activity in inhibiting the growth of different types of cancers, such as lung, ovarian, breast, pancreas, and stomach
cancers are analyzed. Various structural modifications in the A, B, C, D, and E-rings of the camptothecin molecule
have been thoroughly studied to improve bioavailability and diminish toxicity. Modern synthetic approaches to the
camptothecin analogues and several semi-synthetic methods are reviewed.
Publisher
Bentham Science Publishers Ltd.
Subject
Cancer Research,Pharmacology,Molecular Medicine
Reference129 articles.
1. Wall M.E.; Wani M.C.; Cook C.E.; Palmer K.H.; McPhail A.T.; Sim G.A.; Plant antitumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. J Am Chem Soc 1966,88(16),3888-3890
2. Cai J-C.; Hutchinson C.R.; Camptothecin. The Alkaloids: Chemistry and Pharmacology 1983,Vol. 21,101-137
3. Li S.; Zhang W.; Ethnobotany of Camptotheca Decaisne: New discoveries of old medicinal uses. Pharm Crop 2014,5(1),140-145
4. Horwitz S.B.; Chang C.K.; Grollman A.P.; Studies on camptothecin. I. Effects of nucleic acid and protein synthesis. Mol Pharmacol 1971,7(6),632-644
5. Gottlieb J.A.; Luce J.K.; Treatment of malignant melanoma with camptothecin (NSC-100880). Cancer Chemother Rep 1972,56(1),103-105
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献