Development of a Practical and Scalable Synthesis of a Potent CRTH2 Antagonist-Reference-Cited by-同舟云学术

Development of a Practical and Scalable Synthesis of a Potent CRTH2 Antagonist

Published:2012-08-24 Issue:9 Volume:16 Page:1544-1551
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Yoshida Shinya,Yoshino Toshitaka,Miyafuji Akio,Yasuda Hironobu¹,Kimura Takenori²,Takahashi Takumi,Mukuta Takashi

Affiliation:

1. Astellas Research Technologies Co., Ltd., 2-1-6, Kashima, Yodogawa-ku, Osaka 532-8514, Japan

2. Astellas Research Technologies Co., Ltd., 21, Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op3001492

Reference23 articles.

1. Discovery of novel and potent CRTH2 antagonists

2. bTerasaka, T.; Zenkoh, T.; Hayashida, H.; Matsuda, H.; Sato, J.; Imamura, Y.; Nagata, H.; Seki, N.; Tenda, Y.; Tasaki, M.; Takeda, M.; Tabuchi, S.; Yasuda, M.; Tsubaki, K.WO/2008/072784, 2008.

3. Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2

4. Prostaglandin D2Causes Preferential Induction of Proinflammatory Th2 Cytokine Production through an Action on Chemoattractant Receptor-Like Molecule Expressed on Th2 Cells

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