2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H]quinoline-4-carboxylic Acid (PSI-697): Identification of a Clinical Candidate from the Quinoline Salicylic Acid Series of P-Selectin Antagonists-Reference-Cited by-同舟云学术

2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H]quinoline-4-carboxylic Acid (PSI-697): Identification of a Clinical Candidate from the Quinoline Salicylic Acid Series of P-Selectin Antagonists

Published:2006-12-14 Issue:1 Volume:50 Page:40-64
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kaila Neelu¹,Janz Kristin¹,Huang Adrian¹,Moretto Alessandro¹,DeBernardo Silvano¹,Bedard Patricia W.¹,Tam Steve¹,Clerin Valerie¹,Keith James C.¹,Tsao Desirée H. H.¹,Sushkova Natalia¹,Shaw Gray D.¹,Camphausen Raymond T.¹,Schaub Robert G.¹,Wang Qin¹

Affiliation:

1. Chemical and Screening Sciences, Cardiovascular and Metabolic Disease, Drug Safety and Metabolism, Wyeth Research, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060631p

Reference67 articles.

1. Perspectives series: cell adhesion in vascular biology. Role of PSGL-1 binding to selectins in leukocyte recruitment.

2. A Journey with Platelet P-Selectin: The Molecular Basis of Granule Secretion, Signalling and Cell Adhesion

3. Glycosylation in the control of selectin counter-receptor structure and function

4. Regulation of endothelial cell contacts during leukocyte extravasation

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