4-N-, 4-S-, and 4-O-Chloroquine Analogues: Influence of Side Chain Length and Quinolyl Nitrogen pKa on Activity vs Chloroquine Resistant Malaria-Reference-Cited by-同舟云学术

4-N-, 4-S-, and 4-O-Chloroquine Analogues: Influence of Side Chain Length and Quinolyl Nitrogen pKa on Activity vs Chloroquine Resistant Malaria

Published:2008-05-31 Issue:12 Volume:51 Page:3466-3479
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Natarajan Jayakumar K.¹,Alumasa John N.¹,Yearick Kimberly¹,Ekoue-Kovi Kekeli A.¹,Casabianca Leah B.¹,de Dios Angel C.¹,Wolf Christian¹,Roepe Paul D.¹

Affiliation:

1. Department of Chemistry, Department of Biochemistry and Cellular & Molecular Biology, Center for Infectious Disease, Georgetown University, 37th and O Streets, Washington, D.C. 20057

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm701478a

Reference62 articles.

1. The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites

2. A protective paradox

3. Identification of an antimalarial synthetic trioxolane drug development candidate

4. Weak base dispiro-1,2,4-trioxolanes: Potent antimalarial ozonides

5. Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes

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