Development of Highly Potent Inhibitors of Ras Farnesyltransferase Possessing Cellular and in Vivo Activity-Reference-Cited by-同舟云学术

Development of Highly Potent Inhibitors of Ras Farnesyltransferase Possessing Cellular and in Vivo Activity

Published:1996-01-01 Issue:1 Volume:39 Page:224-236
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Leftheris Katerina¹,Kline Toni¹,Vite Gregory D.¹,Cho Young H.¹,Bhide Rajeev S.¹,Patel Dinesh V.¹,Patel Manorama M.¹,Schmidt Robert J.¹,Weller Harold N.¹,Andahazy Mary L.¹,Carboni Joan M.¹,Gullo-Brown Johnni L.¹,Lee Francis Y. F.¹,Ricca Carol¹,Rose William C.¹,Yan Ning¹,Barbacid Mariano¹,Hunt John T.¹,Meyers Chester A.¹,Seizinger Bernd R.¹,Zahler Robert¹,Manne Veeraswamy¹

Affiliation:

1. Departments of Oncology Chemistry, Peptide and Protein Research, and Oncology Drug Discovery, The Bristol-Myers Squibb Pharmaceutical Research Institute, P.O. Box 4000, Princeton, New Jersey 08543-4000

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm950642a

Reference32 articles.

1. Ras C-terminal processing enzymes—New drug targets?

2. Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis.

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