Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders-Reference-Cited by-同舟云学术

Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders

Published:2024-04-03 Issue:15 Volume:146 Page:10393-10406
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Liu Zhonglin¹,Remsberg Jarrett R.¹,Li Haoxin¹,Njomen Evert¹,DeMeester Kristen E.¹,Tao Yongfeng¹^ORCID,Xia Guoqin¹,Hayward Rachel E.¹^ORCID,Yoo Minjin¹,Nguyen Tracey²,Simon Gabriel M.²,Schreiber Stuart L.³⁴^ORCID,Melillo Bruno¹³^ORCID,Cravatt Benjamin F.¹²^ORCID

Affiliation:

1. Department of Chemistry, Scripps Research, La Jolla, California 92037, United States

2. Vividion Therapeutics, San Diego, California 92121, United States

3. Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, Massachusetts 02142, United States

4. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States

Funder

Howard Hughes Medical Institute

National Cancer Institute

Jane Coffin Childs Memorial Fund for Medical Research

Damon Runyon Cancer Research Foundation

Mark Foundation For Cancer Research

Cancer Research UK

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.3c13448

Reference66 articles.

1. Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

2. Reimagining Druggability Using Chemoproteomic Platforms

3. A Chemical Biology View of Bioactive Small Molecules and a Binder‐Based Approach to Connect Biology to Precision Medicines

4. Fragment-based covalent ligand discovery

5. Fragment-Based Approaches in Drug Discovery and Chemical Biology

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