Unusual Base Pair between Two 2-Thiouridines and Its Implication for Nonenzymatic RNA Copying

Author:

Ding Dian12ORCID,Fang Ziyuan3ORCID,Kim Seohyun Chris124ORCID,O’Flaherty Derek K.5ORCID,Jia Xiwen12ORCID,Stone Talbot B.67,Zhou Lijun67ORCID,Szostak Jack W.3ORCID

Affiliation:

1. Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States

2. Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, United States

3. Howard Hughes Medical Institute, Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, United States

4. Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States

5. Department of Chemistry, College of Engineering and Physical Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada

6. Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States

7. Penn Institute for RNA Innovation, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States

Funder

Howard Hughes Medical Institute

University of Pennsylvania

Gordon and Betty Moore Foundation

Alfred P. Sloan Foundation

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

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