Structurally Specific Z-DNA Proteolysis Targeting Chimera Enables Targeted Degradation of Adenosine Deaminase Acting on RNA 1

Author:

Wang Zhen1,Zhang Dingpeng23,Qiu Xing4,Inuzuka Hiroyuki1,Xiong Yan4,Liu Jing1,Chen Li1,Chen He4,Xie Ling56,Kaniskan H. Ümit4,Chen Xian56,Jin Jian4ORCID,Wei Wenyi1ORCID

Affiliation:

1. Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, United States

2. Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, United States

3. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02215, United States

4. Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States

5. Department of Biochemistry & Biophysics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

6. Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 United States

Funder

National Cancer Institute

National Institute on Aging

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

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